Motion-robust, blood-suppressed, reduced-distortion diffusion MRI of the liver
Ruiqi Geng, Yuxin Zhang, James Rice, Matthias R. Muehler, Jitka Starekova, David R. Rutkowski, Nataliya V. Uboha, Ali Pirasteh, Alejandro Roldán-Alzate, Arnaud Guidon, Diego Hernando
Purpose
To evaluate feasibility and reproducibility of liver diffusion-weighted (DW) MRI using cardiac-motion-robust, blood-suppressed, reduced-distortion techniques.
Methods
DW-MRI data were acquired at 3T in an anatomically accurate liver phantom including controlled pulsatile motion, in eight healthy volunteers and four patients with known or suspected liver metastases. Standard monopolar and motion-robust (M1-nulled, and M1-optimized) DW gradient waveforms were each acquired with single-shot echo-planar imaging (ssEPI) and multishot EPI (msEPI). In the motion phantom, apparent diffusion coefficient (ADC) was measured in the motion-affected volume. In healthy volunteers, ADC was measured in the left and right liver lobes separately to evaluate ADC reproducibility between the two lobes. Image distortions were quantified using the normalized cross-correlation coefficient, with an undistorted T2-weighted reference.
Results
In the motion phantom, ADC mean and standard deviation in motion-affected volumes substantially increased with increasing motion for monopolar waveforms. ADC remained stable with increasing motion when using motion-robust waveforms. M1-optimized waveforms suppressed slow flow signal present with M1-nulled waveforms. In healthy volunteers, monopolar waveforms generated significantly different ADC measurements between left and right liver lobes (p =0.0078, reproducibility coefficients (RPC) = 470x10-6mm2/s for monopolar-msEPI), while M1-optimized waveforms showed more reproducible ADC values (p =0.29, RPC=220x10-6mm2/s for M1-optimized-msEPI). In phantom and healthy volunteer studies, both monopolar and motion-robust acquisitions with msEPI showed significantly reduced image distortion (p <0.001) compared to ssEPI. Patient scans showed reduction of wormhole artifacts when combining M1-optimized waveforms with msEPI.
Conclusion
Synergistic effects of combined M1-optimized diffusion waveforms and msEPI acquisitions enable reproducible liver DWI with motion robustness, blood signal suppression, and reduced distortion.