Multidimensional compressed sensing to advance 23Na multi-quantum coherences MRI
Christian Licht, Simon Reichert, Maxime Guye, Lothar R. Schad, Stanislas Rapacchi
Abstract
Purpose
Sodium (23Na) multi-quantum coherences (MQC) MRI was accelerated using three-dimensional (3D) and a dedicated five-dimensional (5D) compressed sensing (CS) framework for simultaneous Cartesian single (SQ) and triple quantum (TQ) sodium imaging of in vivo human brain at 3.0 and 7.0 T.
Theory and Methods
3D 23Na MQC MRI requires multi-echo paired with phase-cycling and exhibits thus a multidimensional space. A joint reconstruction framework to exploit the sparsity in all imaging dimensions by extending the conventional 3D CS framework to 5D was developed. 3D MQC images of simulated brain, phantom and healthy brain volunteers obtained from 3.0 T and 7.0 T were retrospectively and prospectively undersampled. Performance of the CS models were analyzed by means of structural similarity index (SSIM), root mean squared error (RMSE), signal-to-noise ratio (SNR) and signal quantification of tissue sodium concentration and TQ/SQ ratio.
Results
It was shown that an acceleration of three-fold, leading to less than 2×10 min of scan time with a resolution of 8×8×20 mm3 at 3.0 T, are possible. 5D CS improved SSIM by 3%, 5%, 1% and reduced RMSE by 50%, 30%, 8% for in vivo SQ, TQ, and TQ/SQ ratio maps, respectively. Furthermore, for the first time prospective undersampling enabled unprecedented high resolution from 8×8×20 mm3 to 6×6×10 mm3 MQC images of in vivo human brain at 7.0 T without extending acquisition time.
Conclusion
5D CS proved to allow up to three-fold acceleration retrospectively on 3.0 T data. 2-fold acceleration was demonstrated prospectively at 7.0 T to reach higher spatial resolution of 23Na MQC MRI.